|本期目录/Table of Contents|

[1]黄映芳,刘毓秀,陈翠林.非酒精性脂肪性肝病与中心动脉压的相关性研究[J].福建医科大学学报,2019,53(04):257-260.
 HUANG Yingfang,LIU Yuxiu,CHEN Cuilin.Relationship between Non-alcoholic Fatty Liver Disease and Central Blood Pressure[J].Journal of Fujian Medical University,2019,53(04):257-260.
点击复制

非酒精性脂肪性肝病与中心动脉压的相关性研究(PDF)
分享到:

《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第53卷
期数:
2019年04期
页码:
257-260
栏目:
临床研究
出版日期:
2019-08-31

文章信息/Info

Title:
Relationship between Non-alcoholic Fatty Liver Disease and Central Blood Pressure
文章编号:
1672-4194(2019)04-0257-04
作者:
黄映芳1 刘毓秀2 陈翠林1
福建医科大学 附属第一医院,福州 350005 1.全科医学科; 2. 肝病中心
Author(s):
HUANG Yingfang1 LIU Yuxiu2 CHEN Cuilin1
1. Department of General Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; 2. Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
关键词:
非酒精性脂肪性肝病 中心动脉压 反射波
Keywords:
non-alcoholic fatty liver disease central blood pressure reflected wave
分类号:
R256.4; R344.2; R916.4; R977.6; R575.5
DOI:
-
文献标志码:
-
摘要:
目的 探讨非酒精性脂肪性肝病(NAFLD)与中心动脉压(CAP)的相关性。 方法 收集患者的一般资料和血液生化指标、肝脏影像学检查、肱动脉血压及CAP检测报告,参照NAFLD诊断标准分为NAFLD组(433例)及非NAFLD组(244例),采用t检验和卡方检验比较两组资料的差别,采用二元线性Logistics回归探讨影响NAFLD的危险因素。 结果 与非NAFLD组比较,NAFLD组的男性、高血压病、糖尿病、吸烟、饮酒和心血管疾病(CVD)家族史例数较多,体质量指数(BMI)、甘油三酯、极低密度脂蛋白(VLDL)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ谷氨酰转肽酶(GGT)、胆碱酯酶、糖化血红蛋白、空腹血糖、尿酸、肱动脉收缩压(bSBP)、肱动脉舒张压(bDBP)、中心动脉收缩压(cSBP)、中心动脉舒张压(cDBP)显著增高(P<0.01)。糖尿病、BMI、cDBP、CVD家族史和甘油三酯与NAFLD相关(OR值分别为3.003,1.336,1.041,2.287及1.445,P<0.01)。 结论 NAFLD患者的cSBP和cDBP显著升高,cDBP是NAFLD的影响因素之一。
Abstract:
Objective To investigate the relationship between non-alcoholic fatty liver disease(NAFLD)and central blood pressure. Methods This was a retrospective study. A total of 677 patients were included and they were divided into NAFLD group(n=433)and non-NALFD group(n=244). Clinical data, including age, sex, biochemical tests, liver imageological examination, brachial blood pressure and central blood pressure were collected. T test and Chi-square analysis were used to compare the variables between the two groups, and the binary linear regression was used to explore the risk factors for NAFLD. Results Compared with non-NAFLD group, the proportion of male, hypertension, diabetes, smoking, drinking and CVD family history were higher in NAFLD group, and BMI, triglyceride, VLDL, ALT, AST, GGT, cholinesterase, HbA1c, fasting blood-glucose, uric acid, bSBP, bDBP, cSBP and cDBP were significantly higher(P value <0.05)in NAFLD group. Regression showed diabetes(OR=3.003, 95%CI: 1.8564.858, P<0.001), BMI(OR=1.336, 95%CI:1.2291.452, P<0.001), cDBP(OR=1.041, 95%CI:1.0131.069, P=0.004), CVD family history(OR=2.287, 95%CI:1.2684.122, P=0.006), and triglyceride(OR=1.445, 95%CI:1.1041.893, P=0.007)were risk factors of NAFLD. Conclusion The cSBP and cDBP are significantly higher in NAFLD group. cDBP is a risk factor for NAFLD

参考文献/References:

[1] Mc Cullough A J. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease[J]. Clin Liver Dis, 2004,8(3):521-533. [2] White D L, Kanwal F, El-Serag H B. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review[J]. Clin Gastroenterol Hepatol, 2012,10(12):1342-1359. [3] Aronow W S. Nonalcoholic fatty liver disease is associated with coronary artery disease and subclinical atherosclerosis[J]. Future Cardiol, 2016,12(4):393-396. [4] Roman M J, Devereux R, Kizer J, et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the strong heart study[J]. Hypertension, 2007,50(1):197-203. [5] 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 非酒精性脂肪性肝病防治指南(2018年更新版)[J]. 实用肝脏病杂志, 2018,21(2):177-186. [6] Masahide H, Takao K, Noriyuki T, et al.The metabolic syndrome as a predictor of nonalcoholic fatty liver disease[J]. Ann Intern Med, 2005,143(10):722-728. [7] Paolo P, Gianpaolo R, Beilin L J, et al. Added predictive value of night-time blood pressure variability for cardiovascular events and mortality: the ambulatory blood pressure-international study[J]. Hypertension, 2014,64(3):487-493. [8] Mehlum M H, Liest l K, Kjeldsen S E, et al. Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks[J]. Eur Heart J, 2018,39(24):2243-2251. [9] 钟元利, 黄江南, 蒋智渊. 中心动脉压预测心血管事件及全因死亡价值的Meta分析[J]. 广西医科大学学报, 2015,32(3):422-426. [10] Alejandro L S, Guerrero J M R, Javier E G, et al. Nonalcoholic fatty liver disease is associated with blood pressure in hypertensive and nonhypertensive individuals from the general population with normal levels of alanine aminotransferase[J]. Eur J Gastroenterol Hepatol, 2011,23(11):1011-1017. [11] Qian L Y, Tu J F, Ding Y H, et al. Association of blood pressure level with nonalcoholic fatty liver disease in nonhypertensive population: Normal is not the new normal[J]. Medicine, 2016,95(29): e4293. [12] Aneni E C, Oni E T, Martin S S, et al.Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk[J]. J Hypertens, 2015,33(6):1207-1214. [13] 朱小鹏, 张林杉, 颜红梅, 等. 中老年2型糖尿病病人中非酒精性脂肪性肝病与高血压的关系[J]. 实用老年医学, 2017,31(6):19-22. [14] 田青青,吴乃君,陈 茜,等. 2型糖尿病合并非酒精性脂肪肝患者的危险因素分析[J]. 华北理工大学学报(医学版), 2018,20(2):107-111. [15] Sumaiya P, Lawlor D A, Ferreira D L S, et al. The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study[J]. J Hypertens, 2014,33(3):546. [16] Kim J Y, Cho J, Yang H R. Biochemical predictors of early onset non-alcoholic fatty liver disease in young children with obesity[J]. J Korean Med Sci, 2018,33(16):e122. [17] Maryann M, Fernando B, Paola P S, et al. The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease[J]. Hepatology, 2014,61(1):153-160.

相似文献/References:

备注/Memo

备注/Memo:
基金项目: 福建省教育厅中青年教师教育科研基金(JB12111)作者简介: 黄映芳,女,主治医师,医学硕士 通讯作者: 陈翠林. Email: 617154702@qq.com 收稿日期: 2018-10-23
更新日期/Last Update: 2019-10-08