|本期目录/Table of Contents|

[1]吴润华,杨栋勇,黄衍杨,等.阻塞性睡眠呼吸暂停综合征患者左心室质量指数的相关因素分析[J].福建医科大学学报,2016,50(04):247-251.
 WU Runhua,YANG Dongyong,HUANG Yanyang,et al.Analysis of the Related Factors of Left Ventricular MassIndex in Patients with Obstructive Sleep Apnea Syndrome[J].Journal of Fujian Medical University,2016,50(04):247-251.
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阻塞性睡眠呼吸暂停综合征患者左心室质量指数的相关因素分析(PDF)
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第50卷
期数:
2016年04期
页码:
247-251
栏目:
临床研究
出版日期:
2016-08-30

文章信息/Info

Title:
Analysis of the Related Factors of Left Ventricular MassIndex in Patients with Obstructive Sleep Apnea Syndrome
文章编号:
1672-4194(2016)04-0247-05
作者:
吴润华1 杨栋勇2 黄衍杨3 王子燕3
1.福建中医药大学 临床技能教学中心,福州 350122;
2.福建医科大学 附属第二医院呼吸科,泉州 362000;
3. 福建中医药大学 附属人民医院呼吸科,福州 350001
Author(s):
WU Runhua1 YANG Dongyong2 HUANG Yanyang3 WANG ziyan3
1.Teaching Center For Clinical Skill, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;
2.Department of Pulmonary Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China;
3.Department of Pulmonary Medicine, The People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China
关键词:
睡眠呼吸暂停阻塞性 睡眠呼吸暂停综合征 心室功能 基质金属蛋白酶9 金属蛋白酶组织抑制因子1
Keywords:
leep apnea obstructive sleep apnea syndromes ventricular function left matrix metalloproteinase-9 tissue inhibitor of metalloproteinase-1
分类号:
R331.31; R541
DOI:
-
文献标志码:
A
摘要:
目的 探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血清基质金属蛋白酶9(MMP-9)及金属蛋白酶组织抑制因子1(TIMP-1)水平与左心室质量指数(LVMI)的相关性。 方法 OSAS患者60例,根据呼吸暂停低通气指数(AHI)分为轻中度OSAS组(5≤AHI≤30 h-1)及重度OSAS组(AHI>30 h-1),另外收集门诊健康体检者20例作为正常对照组。分别测定3组的血清MMP-9及TIMP-1浓度,行心脏彩超检查计算LVMI。 结果 重度OSAS组的LVMI及血清MMP-9、TIMP-1浓度均高于正常对照组及轻中度OSAS组,差别均有统计学意义(P<0.05)。多元线性回归分析显示,高血压病史、体质量指数(BMI)、AHI及血清MMP-9、TIMP-1水平均是OSAS患者LVMI的影响因素(均为P<0.05)。 结论 OSAS可能是左心室肥厚的独立危险因素,而血清的MMP-9及TIMP-1浓度对评估OSAS患者早期的心室重塑可能具有一定参考价值。
Abstract:
Objective To investigate plasma matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in relationship with left ventricular mass index(LVMI)in patients with obstructive sleep apnea syndrome(OSAS). Methods Sixty OSAS patients who met thediagnosis criteria were divided into 2 groups according to apnea hypopnea index(AHI): mild to moderate group(5≤AHI≤30 times/h)and severe group(AHI>15 times/h). Twenty healthy individuals were included as contro1 cases. Left ventricular mass index(LVMI)were examined,and plasma MMP-9 and TIMP-1 were detected. Results The LVMI and the levels of plasma MMP-9 and TIMP-1 were much higher in severe group than those in the mild to moderate group and the control group(P<0.05). Multi-linear regression analysis indicated that AHI, plasma MMP-9 and TIMP-1 had influence on LVMI in OSAS patients. Conclusion OSAS may be an independent risk factor for the left ventricular hypertrophy, and the levels of plasma MMP-9 and TIMP-1 can be usedas a reference for assessment of early ventricular remodeling in OSAS patients.

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备注/Memo

备注/Memo:
收稿日期: 2016-05-05基金项目: 福建省中青年教师教育科研项目(JA15230)作者单位: 1.福建中医药大学 临床技能教学中心,福州 350122; 2.福建医科大学 附属第二医院呼吸科,泉州 362000; 3. 福建中医药大学 附属人民医院呼吸科,福州 350001作者简介: 吴润华(1977-),女,讲师,福建医科大学2009级博士研究生通讯作者: 杨栋勇. Email: yangdy8800@163.com
更新日期/Last Update: 2016-08-30