|本期目录/Table of Contents|

[1]骆凯,牛刚,薛珍珠,等.不同炎症状态下牙龈组织中髓样细胞触发性受体1的表达[J].福建医科大学学报,2017,51(05):282-286.
 LUO Kai,NIU Gang,XUE Zhenzhu,et al.Expression of Triggering Receptor Expressed on Myeloid Cells1 in Inflamed Gingival Tissue[J].Journal of Fujian Medical University,2017,51(05):282-286.
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不同炎症状态下牙龈组织中髓样细胞触发性受体1的表达(PDF)
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第51卷
期数:
2017年05期
页码:
282-286
栏目:
论著
出版日期:
2017-10-30

文章信息/Info

Title:
Expression of Triggering Receptor Expressed on Myeloid Cells1 in Inflamed Gingival Tissue
文章编号:
16724194(2017)05028205
作者:
骆凯1 牛刚1 薛珍珠1 刘文文2 林凌2 何梦娇1 李艳芬1
福建医科大学1. 附属口腔医院,福建省高校口腔医学重点实验室,福州350002;2. 基础医学院,福州350122
Author(s):
LUO Kai1 NIU Gang1 XUE Zhenzhu1 LIU Wenwen2 LIN Ling2 HE Mengjiao1 LI Yanfen1
1. School of Stomatology, Fujian Medical University & Key Laboratory of Stomatology of Fujian Provincial University, Fuzhou 350002, China; 2. School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China
关键词:
髓样细胞触发性受体 牙周病 牙龈 荧光抗体技术
Keywords:
KEY WORDS:triggering receptor expressed on myeloid cells periodontal disease gingival tissues fluorescent antibody technique
分类号:
R329;R392.11;R781.4
DOI:
-
文献标志码:
A
摘要:
目的观察髓样细胞触发性受体1(TREM1)在不同炎症状态下牙龈组织中的表达情况,探讨TREM1在牙周组织疾病发生过程中的可能作用。方法选择自愿接受本研究的牙周健康人群、慢性牙龈炎患者和慢性牙周炎患者各10例。取30例患者的牙龈组织,固定后常规石蜡包埋,制作连续切片,HE染色行组织学观察,免疫荧光染色观察各组牙龈组织中TREM1的表达情况。结果TREM1定位于细胞膜或细胞质,不同状态牙龈组织的牙龈上皮和结缔组织全层中均有TREM1表达,其中牙周健康组主要分布于牙龈组织上皮层,尤其集中于牙龈上皮基底层,牙龈组织特异性荧光着色强度不明显;慢性牙龈炎组牙龈组织中特异性荧光着色强度为中等阳性,与牙周健康组比较,阳性细胞数量有所增加;慢性牙周炎组牙龈组织中特异性荧光着色强度为强阳性,与牙周健康组及慢性牙龈炎组比较,阳性细胞数量显著增加。结论TREM1在牙龈组织中的表达强度随着牙周组织炎症程度的加重而增强,可能在慢性牙周炎的发生和发展进程中起重要作用。
Abstract:
ABSTRACT:ObjectiveTo detect the distribution and expression of triggering receptor expressed on myeloid cells1 (TREM1) in inflamed gingival tissue.MethodsGingival tissue sections were collected from 10 healthy subjects, 10 gingivitis, and 10 chronic periodontitis.Hematoxylin and eosin staining and immunofluorescence were employed to evaluate the expression of TREM1 in gingival tissues.ResultsTREM1 was detected in the gingival epithelium and connective tissue and was observed localized in cytomembrane and cytoplasm.The expressions of TREM1 in the health subjects were mainly distributed in the gingival epithelium, especially in the basal layer, and the specific staining intensity of the gingival tissue was not obvious.Compared with healthy subjects, TREM1 positive cells increased in the gingivitis group and the specific staining intensity of gingival tissue was moderately positive.In chronic periodontitis group, the expression level of TREM1 was significantly higher than that in both healthy group and gingivitis group.ConclusionThe increased expression of TREM1 is associated with the inflammatory response of gingival tissue and might play important role in the severity and progression of periodontitis.

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备注/Memo

备注/Memo:
作者简介: 骆凯,男,主任医师,医学博士. Email: luokai39@163.com
更新日期/Last Update: 2017-10-30