|本期目录/Table of Contents|

[1]陈 莺,黄 珊,梁 迪,等.白塞病炎症因子谱与疾病活动度的关系初探[J].福建医科大学学报,2018,52(06):404-407.
 CHEN Ying,HUANG Shan,LIANG Di,et al.A Preliminary Study on the Relationship between Inflammatory Cytokines and Immune Imbalance in Behcet's Disease[J].Journal of Fujian Medical University,2018,52(06):404-407.
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白塞病炎症因子谱与疾病活动度的关系初探(PDF)
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第52卷
期数:
2018年06期
页码:
404-407
栏目:
临床研究
出版日期:
2018-12-20

文章信息/Info

Title:
A Preliminary Study on the Relationship between Inflammatory Cytokines and Immune Imbalance in Behcet's Disease
文章编号:
1672-4194(2018)06-0404-04
作者:
陈 莺12 黄 珊2 梁 迪2 魏 博2 薛 原2
1.福建医科大学 临床医学部,福州 350122; 2.厦门中山医院 风湿免疫科,厦门 361004
Author(s):
CHEN Ying12 HUANG Shan2 LIANG Di2 WEI Bo2 XUE Yuan2
1.Department of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China; 2.Rheumatology and Immunology Department, Xiamen Zhongshan Hospital, Xiamen 361004, China
关键词:
溃疡 炎症 C反应蛋白质 血沉 免疫 血管炎
Keywords:
ulcer inflammation C-reactive protein blood sedimentation immunity vasculitis
分类号:
R751; R773.9; R781.9; R977.6
DOI:
-
文献标志码:
A
摘要:
目的 探讨白塞病(BD)患者炎症因子谱的异常表达与疾病活动度、炎症指标等的相关性。 方法 应用RayBiotech细胞因子抗体芯片半定量检测40种血清炎症因子的水平,采用BD疾病活动度评分表评估患者的疾病活动度,采用t检验比较BD患者与健康对照者血清炎症因子水平的差异,采用Pearson相关性分析比较BD患者40种炎症因子与血沉(ESR)、C反应蛋白(CRP)、体液免疫(IgG,IgM,IgA)及活动度评分的相关性。 结果(1)t检验显示,BD患者与健康对照者40种血清炎症因子水平的差别无统计学意义(P>0.05);(2)Pearson相关性分析显示,患者血清中的IL-18,OPN,Resistin,PF4,CD163与BD的疾病活动度、ESR及CRP具有相关性。 结论 IL-18,Resistin,OPN,PF4及CD163等炎症因子可能与BD的疾病活动度有关。
Abstract:
Objective To investigate the abnormal inflammatory factor expression profile in patients with Behcet's disease( BD )and to explore its potential correlation with disease activity and disease inflammatory index( ESR and CRP). Methods Raybiotech cytokine antibody chip was used to semi-quantitatively detect the levels of 40 serum inflammatory factors. BD disease activity scale was used to evaluate disease activity. T test was used to compare the differences in serum inflammatory factors between BD patients and healthy controls. Pearson correlation analysis was used to explore the correlation between 40 inflammatory factors and ESR, CRP, IgG, IgM, IgA and disease activity scores in BD patients. Results(1)There was no significant difference in 40 serum inflammatory factors between BD patients and healthy controls(P>0.05).(2)IL-18, OPN, Resistin, PF4 and CD163 were correlated with BD disease activity, ESR and CRP. Conclusion IL-18, Resistin, PF4, CD163 may be involved in the BD.

参考文献/References:


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备注/Memo

备注/Memo:
收稿日期: 2018-03-17
基金项目: 福建省自然科学基金(2015J010528)
作者单位: 1.福建医科大学 临床医学部,福州 350122; 2.厦门中山医院 风湿免疫科,厦门 361004
作者简介: 陈 莺,女,福建医科大学2016级硕士研究生
通讯作者: 薛 原. Email: xuey168@sina.com
更新日期/Last Update: 2018-12-30