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[1]王 华,张著学,顾 丽,等.抗分枝杆菌药物治疗特发性肉芽肿性乳腺炎的疗效评价[J].福建医科大学学报,2019,53(03):163-167.
 WANG Hua,ZHANG Zhuxue,GU Li,et al.Evaluation of Curative Effect of Anti-mycobacterial Drugs in the Treatment of Idiopathic Granulomatous Mastitis[J].Journal of Fujian Medical University,2019,53(03):163-167.
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抗分枝杆菌药物治疗特发性肉芽肿性乳腺炎的疗效评价(PDF)
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第53卷
期数:
2019年03期
页码:
163-167
栏目:
临床研究
出版日期:
2019-06-30

文章信息/Info

Title:
Evaluation of Curative Effect of Anti-mycobacterial Drugs in the Treatment of Idiopathic Granulomatous Mastitis
文章编号:
1672-4194(2019)03-0163-05
作者:
王 华1 张著学2 顾 丽1 杜葵英1 陈华建1
贵州省人民医院,贵阳 550002 1.乳腺外科; 2.病理科
Author(s):
WANG Hua1 ZHANG Zhuxue2 GU Li1 DU Kuiying1 CHEN Huajian1
1.Department of Breast Surgery, Guizhou Provinical People’s Hospital, Guiyang 550002, China; 2.Department of Pathlogy, Guizhou Provinical People’s Hospital, Guiyang 550002, China
关键词:
乳腺炎 炎症 肉芽肿 分枝杆菌属 药用制剂
Keywords:
mastitis inflammation granuloma mycobacterium pharmaceutical preparations
分类号:
R339.23; R364.3; R655.8
DOI:
-
文献标志码:
A
摘要:
目的 评价抗分枝杆菌三联(异烟肼、利福平、乙胺丁醇)药物治疗特发性肉芽肿性乳腺炎(IGM)的临床疗效。 方法 选取经病理学确诊的80例IGM作为研究对象,分为治疗组55例(抗分枝杆菌三联药物组),对照组25例(未予抗分枝杆菌三联药物组)。所有病例均在治疗后进行定期复查,评估治疗效果。复查期间若达手术条件,则予手术治疗。治疗疗程结束后定期随访,记录复发率。 结果 两组患者治疗前的年龄及体征积分比较,差别无统计学意义(P>0.05)。治疗组经保守治疗治愈率达67.27%,手术治疗前总有效率92.73%; 对照组经保守治疗治愈率达10.91%,总有效率64.0%。两组患者治疗总有效例数比较,差别有统计学意义(P<0.01)。治疗后定期随访1年内,两组复发例数比较,差别有统计学意义(P<0.01)。 结论 抗分枝杆菌三联药物治疗IGM能使大部分患者治愈而避免手术,明显缩小部分患者原发病灶,减少手术切除范围,保留乳房外形,复发率低。
Abstract:
Objective To evaluate the curative effect of anti-mycobacterial triplets(isoniazid, rifampicin, and ethambutol)in the treatment of Idiopathic Granulomatous Mastitis(IGM). Methods A retrospective review was conducted for 80 cases with IGM, which were pathologically diagnosed. The patients were divided into two groups, the treatment group with 55 cases who were treated with anti-mycobacterial drugs and the control group with 25 cases who were treated without taking the drugs. All cases were checked regularly during the treatment period to assess the effect of the treatment. If the lesions were not significantly reduced, the surgical intervention would be performed. After all the treatment courses were completed, there was a follow-up for a year, during which the recurrence rate of each group was recorded. Results Before treatment, there was no statistical significant differences(P>0.05)between treatment group and control group in their age and physical signs. In the treatment group, the cure rate was 67.27% by conservative treatment, the total effective rate was 92.73% before operation. In the control group(40 cases), the cure rate was 10.91%, the total effective rate was 64.0%. The result showed that there was a statistically significant difference between the two groups(P<0.01), and the treatment group was obviously better than the control group in efficacy. A follow-up of 1 year showed that the difference in recurrence rate between the two groups was statistically significant(P<0.01). Conclusisons The anti-mycobacterial drug triplets treatment for IGM can cure most of the patients without needing surgery. Some patients will see a reduction in the size of the lesion, therefore a reduced extent of resection, maintaining the breast appearance and a lower recurrence rate, which is worthy of clinical application.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2018-02-26;基金项目: 贵州省科技厅资助项目(黔科合LH字[2016]7166号,筑科合同[20141001]55号)作者简介: 王 华,男,主治医师,医学硕士通讯作者: 陈华建. Email: gzsychj@163.com
更新日期/Last Update: 2019-06-30