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[1]吴美娜,林 芳,王小勇,等.11例1型发作性睡病睡眠结构的多导睡眠图分析[J].福建医科大学学报,2020,54(01):29-32.
 WU Meina,LIN Fang,WANG Xiaoyong,et al.A Study of Sleep Architecture in 11 Cases of Type 1 Narcolepsy by Polysomnogram[J].Journal of Fujian Medical University,2020,54(01):29-32.
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第54卷
期数:
2020年01期
页码:
29-32
栏目:
临床研究
出版日期:
2020-02-28

文章信息/Info

Title:
A Study of Sleep Architecture in 11 Cases of Type 1 Narcolepsy by Polysomnogram
文章编号:
1672-4194(2020)01-0029-04
作者:
吴美娜 林 芳 王小勇 陈海泓 季晓林 严金柱
福建省级机关医院,福建卫生职业技术学院 附属医院神经内科,睡眠医学中心,福州 350003
Author(s):
WU Meina LIN Fang WANG Xiaoyong CHEN Haihong JI Xiaolin YAN Jinzhu
Department of Neurology,Sleep Medical Center,Fujian Province Governmental Hospital, The Affiliated Hospital of Fujian Health College,Fuzhou 350003, China
关键词:
发作性睡病 睡眠 分泌素 下丘脑
Keywords:
narcolepsy sleep secretin hypothalamus
分类号:
R338.63
DOI:
-
文献标志码:
A
摘要:
目的 探讨1型发作性睡病夜间睡眠的结构特点。 方法 收集1型发作性睡病患者11例和有日间嗜睡但排除相关睡眠疾病的儿童20例。使用多导睡眠监测仪进行整夜(>7 h)连续包括16导脑电图的视频多导睡眠监测(PSG),并于次日进行5次多次小睡潜伏期试验(MSLT)。 结果 与对照组比较,1型发作性睡病组在入睡后觉醒时间占总卧床时间的百分比(WASO%)、非快速眼球运动(NREM)1期睡眠期比例(N1%)增加[17.60(13.10)vs 5.00(12.80),P<0.05;(19.93±12.00)vs(10.12±5.63),P<0.05],入睡潜伏期、快速眼球运动(REM)睡眠潜伏期缩短[5.50 min(11.50 min)vs 13.50 min(22.87 min),P<0.05;(93.50±106.61)min vs(157.47±65.74)min,P<0.05],NREM 3期睡眠期比例(N3%)减少[(17.50±5.60)vs(24.48±7.60),P<0.05]; 但睡眠效率、NREM 2期睡眠期比例(N2%)、REM睡眠期比例(R%)、醒觉指数、睡眠期周期性腿动指数、睡眠呼吸暂停/低通气指数等差别无统计学意义。 结论 1型发作性睡病患者存在夜间睡眠结构紊乱、睡眠片段化现象。
Abstract:
Objective To explore the characteristics of night sleep structure in type 1 narcolepsy. Methods The enrolled subjects were: 11 type 1 narcolepsy patients and 20 controls who complained of daytime sleepiness,but with no sleep related diseases. All subjects attended neurology clinic from January 2007 to December 2017. All subjects underwent overnight(>7 h)consecutive video-polysomnography(vPSG)with 16 channel electroencephalograph(EEG)and multiple sleep latency test(MSLT)including five nap opportunities in the next day. Results Compared with the control group, type 1 narcolepsy had more wake time after sleep onset(WASO)in percentage of time in bed(WASO%)and increased NREM 1 sleep period(N1)%[17.60(13.10)vs 5.00(12.80),P<0.05;(19.93±12.00)vs(10.12±5.63), P<0.05], shorter sleep latency and REM sleep latency[5.50 min(11.50 min)vs 13.50 min(22.87 min), P<0.05;(93.50±106.61)min vs(157.47±65.74)min,P<0.05], less NREM 3 sleep period(N3)%[(17.50±5.60)vs(24.48±7.60), P<0.05). There was no significant difference in sleep efficiency, NREM 2 sleep period(N2)%, REM sleep period(R)%, awakening index, sleep periodic leg movement index, and sleep apnea hypopnea index(AHI). Conclusion There are abnormal sleep structure in night sleep and sleep fragmentation in patients with type 1 narcolepsy patients.

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备注/Memo

备注/Memo:
收稿日期: 2019-03-29 作者简介: 吴美娜,女,主治医师,医学硕士 通讯作者: 严金柱. Email:yjzfz@126.com
更新日期/Last Update: 2020-01-30