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[1]林亚娟,徐 伟,叶 淼,等.盐肤木总酚酸微丸对大鼠急性心肌缺血的保护作用[J].福建医科大学学报,2020,54(02):86-90.
 LIN Yajuan,XU Wei,YE Miao,et al.Protective Effects of Rhus Chinensis Mill. Total Phenolic AcidPellets on Acute Myocardial Ischemia in Rats[J].Journal of Fujian Medical University,2020,54(02):86-90.
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第54卷
期数:
2020年02期
页码:
86-90
栏目:
论著
出版日期:
2020-04-30

文章信息/Info

Title:
Protective Effects of Rhus Chinensis Mill. Total Phenolic AcidPellets on Acute Myocardial Ischemia in Rats
文章编号:
1672-4194(2020)02-0086-05
作者:
林亚娟1 徐 伟1 叶 淼1 褚克丹1 卢晓艺1 连 红2 王晓颖1
1.福建中医药大学 药学院,福州 350122; 2.福州海王金象中药制药有限公司,福州 350014
Author(s):
LIN Yajuan1 XU Wei1 YE Miao1 CHU Kedan1 LU Xiaoyi1 LIAN Hong2 WANG Xiaoying1
1.College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; 2.Fuzhou HaiWangJinXiang Traditional Chinese Medicine Co., Ltd, Fuzhou 350014, China
关键词:
丸剂 心肌缺血 垂体激素类 后叶 心电图
Keywords:
pills myocardial ischemia pituitary hormones posterior electrocardiography
分类号:
R542.2
DOI:
-
文献标志码:
A
摘要:
目的 观察盐肤木总酚酸微丸对垂体后叶素(pit)诱导的大鼠急性心肌缺血的预防性保护作用。 方法 将56只雄性大鼠随机分为阳性对照组(地奥心血康胶囊0.061 3 g/kg组和硝苯地平6.13 mg/kg组)、盐肤木粗提物组(9.2 g/kg)、盐肤木总酚酸组(0.195 g/kg)、盐肤木总酚酸微丸组(0.68 g/kg)、对照组和模型组(给予相同体积的生理盐水),连续灌胃给药10 d,末次给药2 h后舌下静脉注射pit造成大鼠急性心肌缺血,观察并记录大鼠心电图的变化,研究盐肤木总酚酸微丸对血清中乳酸脱氢酶(LDH)和肌酸激酶(CK)的影响。 结果 模型组大鼠心电图ST段显著抬高和T波倒置,对照组未见异常,各给药组大鼠心电图有不同改善,盐肤木总酚酸微丸对pit所致急性心肌缺血大鼠心电图及心率的变化有明显的改善作用,同时对心肌缺血和心律失常情况均有所改善,明显降低血清中LDH和CK的活性。 结论 盐肤木总酚酸微丸对pit所致的大鼠急性心肌缺血具有较明显的预防保护作用。
Abstract:
Objective To observe the protective effects of Rhus Chinensis Mill. total phenolic acid pellets on acute myocardial ischemia induced by sublingual injection of pituitrin(pit)in rats. Methods 56 male rats were randomly divided into positive groups(Diaoxinxuekang capsules 0.061 3 g/kg and nifedipine 6.13 mg/kg), crude extract of Rhus Chinensis Mill. 9.2 g/kg, Rhus Chinensis Mill. total phenolic acid 0.195 g/kg, Rhus Chinensis Mill. total phenolic acid pellets 0.68 g/kg, normal group, and model group. The normal and model groups were given the same volume of normal saline. After intragastrical administration for 10 d, an acute myocardial ischemia model was induced by the injection of pituitrin in the rats’ tongue sublingual intravenous injection of pit at 2 h after the last administration, and electrocardiograph was observed and recorded. Meanwhile, the effect of Rhus Chinensis Mill.total phenolic acid pellets on serum lactate dehydrogenase(LDH)and creatine kinase(CK)were investigated. Results After modeling, the model group showed significant ST segment elevation and T wave inversion, while the normal group was not found abnormal. The electrocardiogram of each administration group was improved to different extents. Rhus Chinensis Mill. total phenolic acid pellets significantly improved electrocardiogram and heart rate in rats with acute myocardial ischemia induced by pit. At the same time, the pellets reduced the incidence of myocardial ischemia and arrhythmia. The pellets reduced the activities of LDH and CK in serum. Conclusion Rhus Chinensis Mill. total phenolic acid pellets have significant preventive protection effect on acute myocardial ischemia in rats induced by pit.

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备注/Memo

备注/Memo:
收稿日期: 2019-10-15基金项目: 国家自然科学基金(81803678)作者简介: 林亚娟,女,福建中医药大学2019级硕士研究生通讯作者: 王晓颖. Email:wangxy623@yeah.net
更新日期/Last Update: 2020-04-30