|本期目录/Table of Contents|

[1]王清,王欣.胎儿颈后皮下积液内分隔与染色体异常的相关性[J].福建医科大学学报,2020,54(04):264-268.
 WANG Qing,WANG Xin.Relationship between Septum of Nuchal Subcutaneous Hydrops and Chromosomal Anomalies[J].Journal of Fujian Medical University,2020,54(04):264-268.
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胎儿颈后皮下积液内分隔与染色体异常的相关性(PDF)
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《福建医科大学学报》[ISSN:1672-4194/CN:35-1192/R]

卷:
第54卷
期数:
2020年04期
页码:
264-268
栏目:
临床研究
出版日期:
2020-09-10

文章信息/Info

Title:
Relationship between Septum of Nuchal Subcutaneous Hydrops and Chromosomal Anomalies
文章编号:
1672-4194(2020)04-0264-05
作者:
王清 王欣
首都医科大学 附属北京妇产医院产科,北京100026
Author(s):
WANG Qing WANG Xin
Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, Beijing 100026, China
关键词:
染色体畸变 妊娠初期 颈后隔膜
Keywords:
chromosome aberrations pregnancy trimester first nuchal septations
分类号:
R323.1; R341.6; R394.2; R596.1
DOI:
-
文献标志码:
A
摘要:
目的评估早孕期胎儿颈后皮下积液内分隔与染色体异常的关系。方法将2014年1月- 2016年12月早孕期超声检查提示颈项透明层(NT)增厚NT≥3 mm或颈后皮下积液出现分隔(NS)、接受侵入性产前诊断的胎儿281例纳入研究。将281例孕妇分为3组:NT厚度为3.0~5.0 mm且颈后皮下积液未发现分隔的胎儿(NT 3.0~5.0 mm组,n=124); NT厚度>5 mm且颈后皮下积液未发现分隔的胎儿(NT>5.0 mm组, n=96); 出现NS的胎儿(NS组,n=61)。结果NS组胎儿染色体异常率明显高于NT 3.0~5.0 mm组和 NT> 5 mm组( P<0.01)。经调整孕妇年龄、妊娠前体质量指数、种族、头臀长,NS组较NT 3.0~5.0 mm组( OR=4.97; 95% CI:2.76~10.77; P<0.01)和NT>5 mm组(OR=3.82; 95% CI:1.87~7.21; P<0.01)胎儿发生染色体非整倍体的风险更显著。结论颈后皮下积液是否存在分隔在妊娠早期染色体非整倍体筛查中可能可以作为一个有意义的筛查指标。
Abstract:
ObjectiveTo evaluate the association of nuchal septations with chromosomal anomalies during the first trimester of pregnancy.MethodsA total of 281 patients who were diagnosed to have elevated nuchal translucency(NT≥3 mm)or nuchal septations during the first trimester from Jan.2014 to Dec.2016 were included.These patients were divided into three groups:Patients with NT thickness 3-5 mm and without nuchal septations(NT 3-5 mm group, n=124); Patients with NT thickness > 5 mm and without nuchal septations(NT>5 mm group, n=96); patients with nuchal septations(NS group, n=61).ResultsThe rate of chromosomal abnormalities was significantly higher for patients in NS group compared to those in the NT 3-5 mm group(P<0.01)and NT>5 mm group(P<0.01).After controlling for maternal age, maternal BMI, ethnicity and crown-rump length, nuchal septations were reported to be significantly associated with a higher risk of aneuploidy compared with NT 3-5 mm( OR=4.97; 95% CI: 2.76-10.77; P<0.01)and NT>5 mm(OR=3.82; 95% CI: 1.87-7.21; P<0.01).ConclusionsMeasurement of nuchal septations during the first trimester of pregnancy proves to be a useful ultrasound prognostic indicator of chromosomal anomalies.

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备注/Memo

备注/Memo:
收稿日期: 2019-12-04作者简介: 王清,女,副主任医师,医学硕士 通讯作者: 王欣. Email: wx1501@aliyun.com
更新日期/Last Update: 2020-10-15